Iron content in cerebrospinal fluid (CSF) as novel biomarker for early diagnosis of dementia.
underline Ficiará E., Ansari S., Boschi S., Cattaldo S., Ruffinatti F.A., Stura I., Abollino O., Rainero I., Mauro A., Guiot C.
V - Biofisica e fisica medica
GSSI Ex ISEF - Aula B - Martedì 24 h 09:00 - 12:00
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Iron is an essential element for many biological functions. Iron homeostasis in the brain results from a dynamic exchange between blood and cerebral space, maintained by the blood brain barrier (BBB) system. Imbalance of iron metabolism is involved in several neurodegenerative disorders, such as Alzheimer's disease, leading to accumulation phenomena at tissue level. Accurate detection of iron in CSF is performed using Graphite-Furnace Atomic Absorption Spectrometry on samples from patients affected by dementia and matched controls for a total of 80 cases. $In vitro$ and $in silico$ models of BBB are carried out to investigate how iron trafficking affects its concentration in CSF.