Longitudinal MRI follow-up of ultrasound-induced blood-brain barrier disruption.
Conti A., Geffroy F., Kamimura H., Mériaux S., Larrat B.
V - Biofisica e fisica medica
GSSI Ex ISEF - Aula B - Martedì 24 h 09:00 - 12:00
» Download abstract
Focused Ultrasound in conjunction with microbubbles open locally the BBB. This technique is safe in a narrow range of Acoustic Pressure (AP). Here we wanted to investigate what happens to the brain tissues at short and long-terms in case of an excessive AP is reached in vivo. BBB opening, T1,2 weighted images, T2*-maps, DWI, MRS acquisitions and histological analyses have been performed within 28 days after BBB opening. Pgp expression, cells deaths, and astrocytes/microglial activations have been imaged within 28 days. Our results show that neuroinflammation induced by FUS application may persist for up to 28 days.