Reconstructing conductive phenomena induced in heterogeneous brain tissue by Transcranial Magnetic Stimulation (TMS).
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V - Biofisica e fisica medica
Aula 32C-2 - Mercoledì 19 h 09:00 - 13:00
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We solve the bioelectromagnetic problem of TMS over a realistic head model based on multimodal neuroimaging. We use Monte-Carlo methods to investigate the dependence of stimulation outcome on tissue type, geometry, and conductivity tensor size and shape on a voxel- and vertex-wise level. Conductivity anisotropy plays an important role in introducing uncertainty, and the complex folding patterns of the human brain play a significant role in shaping not stimulation patterns in space and their susceptibility to uncertainties in model parameters. We validate our results in humans and show a dose-response relationship of TMS when used for treating major depression.