Normal brain aging assessment by Transient Anomalous diffusion MRI metrics
Capuani S., Caporale A., Guerreri M., Gabrielli A.
Relazione su invito
V - Biofisica e fisica medica
GSSI Ex ISEF - Aula B - Martedì 24 h 17:30 - 19:30
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The nuclear magnetic resonance signal obtained using a radiofrequency-pulses and magnetic-field gradients sequence, is proportional to the Fourier Transform of the motion propagator describing molecular diffusion of biological water in tissues. We developed a new imaging contrast metrics derived from anomalous diffusion motion propagator and obtained from diffusion-weighted (DW) magnetic resonance imaging data. Transient anomalous diffusion maps of human brains at different ages identify myelin density decline and mirror iron accumulation. The new metrics together with conventional diffusion-metrics based on Gaussian diffusion, can more comprehensively characterize the complex mechanisms underlining age-related changes in human brain than conventional diffusion techniques alone.