MRI-guided Radiotherapy: seeing what to treat!
Van den Berg C.N.
V - Biofisica e fisica medica
Aula 29B-1 - Mercoledì 19 h 16:30 - 17:30
» Download abstract
External beam radiotherapy treats an invisible target (tumor) with an invisible high energy photon beam. This invisibility poses a fundamental challenge and has been the drive behind the introduction of imaging technology in radiotherapy. This development started with the use of X-ray projections revealing only bony anatomy, advancing to 3D images by means of CT imaging in the late nineties and finally now, to direct onboard MR imaging during radiation therapy. The key advantage of MRI at the time of treatment is that it allows direct 3D visualization of soft tissue target structures. This MRI-guidance is changing our current treatment paradigm where a pre-defined static radiation plan is replicated over many radiation fractions, to a scheme where treatment occurs in much less fractions enabled by dynamically adapting the radiation plans based on real-time incoming imaging data. This talk will discuss the innovations that have enabled this shift. In the first part of this talk, the physical and engineering hurdles that had to be overcome to integrate a linear accelerator with an MRI scanner will be discussed. In the second part of the talk, advancements in enabling technologies such as radiation planning, MRI and image processing technology will be reviewed.