Low dose/dose rate (LDR) gamma irradiation renders Drosophila melanogaster resistant to DNA damage.

Cipressa F., Porrazzo A., Morciano P., Esposito G., Tabocchini M.A., Cenci G.

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We found that D. melanogaster flies, chronically exposed to a priming $\gamma$-radiation dose of 40 cGy, at a dose rate of 2.5 mGy/h (LDR), exhibited a strong reduction ($\sim$50%) of chromosome break after a challenge dose of 10 Gy compared to flies directly exposed to 10 Gy. This indicates that LDR in flies induces an adaptive response to genotoxic threats rendering this model organism resistant to DNA damage. Our RNA-seq data revealed that this response is associated with changes in the expression of few genes. Our results are expected to shed more light on the in vivo effects of LDR also in humans.

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