X-ray phase contrast tomography for the investigation of ALS disease.
Begani Provinciali G., Fratini M., Bukreeva I., Palermo F., Pieroni N., Maugeri L., Mittone A., Bravin A., Gigli G., Quattrini A., Cedola A.
V - Biofisica e fisica medica
Aula 32C-2 - Giovedì 20 h 09:00 - 13:00
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X-ray Phase-Contrast Tomography is a multiscale technique that enables the study of 3D alterations in vascular and neuronal networks at relevant disease phases of the animal model (SOD) for Amyotrophic Lateral Sclerosis (ALS), without sample sectioning or specific preparation. We provide a deeper knowledge on the degeneration of motor-neurons in the central nervous system diseases as well as the monitoring of treatment efficacy in ALS, at different stages of the disease. The analysis is been extended to the peripheral nervous system as its degeneration precedes the death of the neuronal cells and would therefore represent a marker for early diagnosis.