Micro-computed tomography imaging of brain cancer radiotherapy.
Barbone G.E., Bravin A., Romanelli P., Mittone A., Bucci D., Gaass T., Le Duc G., Auweter S., Reiser M., Kraiger M. J., Hrabu e de Angelis M., Battaglia G., Coan P.
V - Biofisica e fisica medica
Aula 32C-2 - Giovedì 20 h 09:00 - 13:00
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X-ray Phase Contrast CT (PCI-CT) is an experimental imaging methodology, which simultaneously provides micrometric spatial resolution, high soft-tissue sensitivity and $ex vivo$ full-organ rodent brain coverage without any need for sample dissection, staining/labeling or contrast agent injection. We explore here the benefits and limitations of PCI-CT use for the $in vitro$ imaging of normal and cancerous brain neuro-morphology after $in vivo$ treatment with synchrotron-generated X-ray Microbeam Radiation Therapy (MRT), a spatially fractionated experimental high-dose radiosurgery. The goals are the visualization of MRT treatment effects on nervous tissue, and qualitative comparison of results to histology and high-field MRI.