Systematic analysis of RBE and LQ parameters using a database of different cell line survival experiments with clinical proton beam.
Pandola L., Cirrone G.A.P., Khanna R., Cammarata F.P., Colelli G., Chidera O., Cuttone G., Russo G., Petringa G.
V - Biofisica e fisica medica
GSSI Ex ISEF - Aula B - Giovedì 26 h 09:00 - 12:30
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Currently, in proton therapy, a generic value of 1.1 is used in treatment planning systems, which disregards variations in the RBE. The database consists of 20+ different cell survival experiments, performed at the multidisciplinary beamlines of INFN-LNS, after photon and proton irradiation. The Linear Quadratic (LQ) alpha and beta parameters are used in the SURVIVAL code to compute look-up tables (LUT's) which are used in the GEANT4 simulation to give simulated LQ parameters in the mixed-field condition. This aims to enable the simulation of the cell lines through GEANT4 for accurate estimation of RBE in treatment planning systems.