X-ray Phase Contrast Tomography for the investigation neurodegenerative diseases.

Cedola A., Bravin A., Bukreeva I., Fratini M., Pacureanu A., Mittone A., Massimi L., Cloetens P., Coan P., Campi G., Brun F., Petrosino V., Venturi C., Mastrogiacomo M., Kerlero de Rosbo N., Uccelli A.

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We apply X-ray Phase Contrast Tomography (XPCT) to evaluate neurovascular alterations at relevant disease phases of the animal model for multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) and we investigated the efficacy of mesenchymal-stem-cells therapy. A direct 3D morphological description of EAE vascular and neuronal lesions is provided at two different length scales, spanning from mm down to 50 nm. Such a multi-scale direct analysis has never been performed to understand EAE pathology and gives a breakthrough in the research of neurodegenerative diseases. We applied multiscale-XPCT also to the investigation of Alzheimer disease and the impressive results obtained will be presented.

Società Italiana di Fisica - Via Saragozza 12 40123 Bologna P.IVA 00308310374 | credits