# Enhanced proton therapy: The Neptune project.

Cuttone G.

Relazione su invito
V - Biofisica e fisica medica
GSSI Ex ISEF - Aula B - Venerdì 27 h 09:00 - 12:00
One shortcoming of proton therapy is its inability to treat radioresistant cancers, being protons radiobiologically almost as effective as photons. Heavier particles, such as 12C ions, can overcome radioresistance but they present radiobiological and economic issues that hamper their widespread adoption. Therefore, many strategies have been designed to increase the biological effectiveness of proton beams. The goal of this project is to investigate the use of nuclear reactions triggered by protons generating short-range high-LET alpha particles inside the tumours, thereby allowing a highly localized DNA-damaging action. Specifically, we intend to consolidate and explain the promising results recently published where a significant enhancement of biological effectiveness was achieved by the p-${}^{11}B$ reaction. Moreover, the p-${}^{19}F$ reaction, which also generates secondary particles potentially leading to local enhancement of proton effectiveness, will be investigated.