The CapsuLight project: From in vitro studies to intra-gastric robotic device prototyping for antibacterial phototherapy against Helicobacter pylori.
Romano G., Gnerucci A., Faraoni
P., Orsini B., Ranaldi F., Morici
P., Battisti A., Sgarbossa A., Ghetti F., Checcucci G., Menciassi A., Tortora G., Fusi F.
V - Biofisica e fisica medica
Aula 32C-2 - Venerdì 21 h 15:30 - 18:30
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The CapsuLight project, financed by the Tuscany Region, is inserted in the framework of antibacterial photodynamic therapy and merges research in the photonics, robotics, photophysics and gastroenterology fields. Its objectives are: (i) to design, build and characterize the emission and safety of a minimally-invasive robotic device in the form of a luminous capsule for Helicobacter pylori photo-killing in the stomach, with no use of external photosensitizers. Starting from in vitro experiments, the project has studied the in vivo photo-killing action spectrum, on which basis specific LED sources have been mounted on the final device prototypes, whose emission and safety have been characterized in laboratory conditions; (ii) to project and characterize pH sensors, to turn off the capsule in the intestine; (iii) to perform preliminary studies of healthy tissue possible sensitization.