Analytical and Monte Carlo approaches for the radiobiological in vitro study of radioresistant breast adenocarcinoma (MDA-MB-231) cell line with clinical proton beam.

Chiappara D., Petringa G., Chidera O., Cammarata F.P., Colelli G., Cuttone G., Forte G., Khanna R., Minafra L., Russo G., Cirrone G.A.P.

V - Biofisica e fisica medica
GSSI Ex ISEF - Aula B - Venerdì 27 h 15:30 - 19:00
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The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters commonly used in the investigation of the in vitro behaviour of radioresistant breast adenocarcinoma (MDA-MB-231) cells line with clinical proton beam for clinical relevance. The experimental conditions were fully simulated and cell survival fractions were calculated by linking the simulations with analytical radiobiology models: Local Effect Model (LEM) and Microdosimetric Kinetic Model (MKM). Results were evaluated and compared with experimental data. The results demonstrated excellent agreement with experimental data for lower doses (0--6 Gy) and more.

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