Theranostic nanocarriers with magnetic properties for innovative medical applications.
D'Agata F., Albertini F., Ansari S., Ficiarà E., Zullino S., Argenziano M., Cavalli R., Guiot C.
V - Biofisica e fisica medica
GSSI Ex ISEF - Aula B - Lunedì 23 h 15:00 - 19:00
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Nanocarriers (NCs) decorated with magnetic nanoparticles ($e.g.$, SPIONS) may expand their theranostic features to wider applications both for imaging (MRI, magnetic imaging) and for therapy. We investigated how magnetic oxygen-carrying NCs in the presence of magnetic fields may induce hyperthermia releasing oxygen within the tumor at the same time. Both non-thermic and thermic effects may also favour membrane trespassing allowing focalized drug delivery across the Blood Brain Barrier (BBB) in degenerative CNS diseases and performing adjuvant functions ($e.g.$, chelating metallic ions, disrupting plaques, etc.) under direct monitoring by MRI and magnetic imaging.