Nanoparticles uptake within the brain tissue after FUS-induced BBB disruption: An empirical and theoretical study.
Conti A., Magnin R., Gerstenmayer M., Mériaux S., Della Penna S., Larrat B.
V - Biofisica e fisica medica
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Low-intensity Focused Ultrasound (FUS) combined with microbubbles open the Blood-Brain Barrier (BBB) locally and noninvasively, allowing the passage of nanoparticles into the brain. However, so far a model fully predicting the result of a FUS induced BBB opening experiment is missing. We introduce a mathematical model depicting both the vascular permeability as a function of time and the diffusion process occurring in brain tissue. This model takes into account acoustic pressure, particle size, blood pharmacokinetics and diffusion rates. The match with the experimental data proves the feasibility of this method to plan drug distribution after a BBB opening experiment.