Nano-sphere lithography fabrication of large-area ordered arrays plasmonic nanostructures for high-sensitivity biosensors.
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Highly ordered arrays of plasmonic nanostructures have been fabricated by a simple and reproducible approach based on nano-sphere lithography (NSL). This cost-effective method is based on the self-assembling of close-packed polystyrene (PS) particles at air/water interface, and enables the fabrication of colloidal mask characterized by a high quality crystal structure. An optical biosensor based on localized surface plasmon resonance has been developed for the sensitive detection of Lipopolysaccharides (LPS). A good linear relationship between peak shifts and the LPS concentration has been demonstrated ($< 10$ ng/ml). Further applications in quality control of pharmaceutical preparations and medical devices are in progress.